Abstract

Mandelic acid is called ‘German mandel-almond’. It is a natural alphahydroxy acid, derived from amygdalin, a glycoside which is found in peaches, bitter almonds & apricots. It has a phenyl group as a side chain in its chemical structure, which changes its solubility profile, making it more lipophilic compared to the other conventional water-soluble alphahydroxy acids. All the patients attending the dermatology OPD were screened for periorbital melanosis. Detailed history was taken and clinical examination was performed in the patients with periorbital melanosis. Dermatological examination of the periorbital area was also done to determine the type of periorbital melanosis (vascular and structural type were excluded by a stretch test). 30 patients who fulfilled the inclusion and exclusion criteria were enrolled for the study after explaining the study requirement in the language they understand and written informed consent was taken. Test peel was done in the retroauricular area skin before starting the treatment. In the study, there was no significant difference in mild burning sensation, frosting, dryness and pruritus between the two sides treated with 40% mandelic acid and 40% lactic acid peels. There was significant difference in severe burning sensation between the two sides. On right side treated with 40% mandelic acid peel, 10% had severe burning sensation and on left side treated with 40% lactic acid peel, 33.3% had severe burning sensation.

Description