Abstract

The aim of the present study was to assess the Comparison of Dexmedetomidine, midazolam and propofol for sedation of post operative patients on mechanical ventilation. Methods: This single blinded, open label, randomized control trial conducted in the Department of Anaesthesia for 1 year. 90 patients were equality divided into 3 groups, 30 in each group. Results: The difference in demographic profile among the three groups was not statistically significant. In our study we found that difference of mean HR at different time interval was not statistically significant but compared to group M & P, HR falls more in group D and the mean HR was less in Dexmedetomidine group. No statistically significant difference in SBP & DBP among all these groups. Conclusion: Dexmedetomidine is safer and equally effective agent compared to propofol and midazolam for sedation of mechanically ventilated patients with good hemodynamic stability and extubation time as rapid as propofol. Dexmedetomidine also reduced postoperative fentanyl requirements.

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