Abstract

Osteoarthritis (OA) is chronic progressive, softening and disintegration of articular cartilage and new growth of cartilage and bone at joint margins. So many non surgical modalities of treatment are being developed to delay the surgery for osteoarthritis. Out of which PRP is being widely used. The purpose of this study was to evaluate functional outcome of intraarticular platelet-rich plasma in osteoarthritis knee joints. Materials and Methods: It is a prospective randomized study conducted from March 2021 to March 2022 on 100 osteoarthritis knee joints, selected from the Outpatient Department of Orthopedics, at Government Medical College, Kadapa. Clinical examination and x rays of the knee joints were done and blood sample of the patients were collected and PRP prepared in the Department of Pathology of the same institute. Injection was done in Operation Theatre under strict aseptic conditions. Patients were assessed with WOMAC (Western Ontario McMaster Universities Arthritis Index) scoring pre injection of PRP and post injection period of 1 month, 3 month and 6 months. A reduction in WOMAC score is suggestive of improvement in the patient's condition. Results: A Prospective study with 50 patients with bilateral primary osteoarthritis (100 knees) grade 1/2 to study clinical and functional outcome of intraarticular PRP. Out of 100 knees, 40 were males, 60 were females, 45 were grade 1, 55 were grade 2. According to Womac score, grade of result in group A – poor - 4, fair - 10, good - 32, excellent – 54. On assessing the results, there is a significant improvement in WOMAC score of all the patients and the results sustained for 6 months. Though clinically better results are seen in grade I knee joints than grade II knee joints, the difference is statistically not significant. Conclusion: We can safely conclude that Intraarticular Autologous PRP injection in Osteoarthritis (Grade I and Grade II) of Ahlback's radiological grading gives relief from pain, stiffness and improves physical functionality without major side effects and can be used as modality of treatment.

Description