Abstract

To study etiology and clinical profile of pancytopenia patients Design :Crosscectional study Setting :A large, academic, tertiary medical center Methodology: Clinicohematological parameters including laboratory data of all patients with a primary diagnosis of pancytopenia was taken . The various etiological factors, clinical presentations and lab investigations were taken into account and compared and prognosis was assessed for each patient Results: A male preponderance was observed, and the majority of patients were aged above 60 years. The most common clinical features were pallor and splenomegaly. Common PS finding was NCNC anaemia.67 percent of patients had hemoglobin less than 7 g%; whereas around 50% of the sample had WBC < 2000 and platelets less than 50000, 52 % had vitamin B12 deficiency, 32% had folic acid deficiency and 19% had a deficiency of both. The most common cause of pancytopenia was Vitamin B12 deficiency.Most common malignancy associated with pancytopenia was AML. Interpretation and conclusion: Several easily recognisable and treatable conditions can manifest as pancytopenia. Prompt management of such conditions, notably sepsis and megaloblastic anaemia, can result in the resolution of the cytopenias and negate the need for a BME. Pancytopenia investigations, when guided by appropriate clinic-laboratory findings, can promptly identify the underlying aetiology, while also identifying cases where an expedited BME is required

Description