Abstract

Vasopressors for prophylaxis and treatment of spinal hypotension have grown in popularity in recent years. Norepinephrine is now emerging as one of the feasible options for prevention as well as management of spinal-induced hypotension in caesarean section. The aim of our study was to compare the efficacy of two different doses of norepinephrine as prophylaxis for spinal-induced hypotension during CS. Materials and Methods: Total 80 patients were recruited in this prospective randomized double-blind study after fulfilling the inclusion and exclusion criteria, undergoing elective CS under spinal anesthesia, who were assigned into two groups of 40 patients each. Group N6 received norepinephrine 6 μg as an intravenous and Group N5 received norepinephrine 5 μg, simultaneously with subarachnoid block. Incidence of hypotension, requirement of rescue doses of norepinephrine, hemodynamic parameters, adverse effects, and neonatal complications were assessed, compared and analyzed. All statistical program using SPSS 21 version statistical program for Microsoft Windows. Results: Both groups were comparable in terms of age, weight, height and side effects. The incidence of spinal induced hypotension was significantly higher in group N5 as compared to group N6 and continued to show higher hypotension incidence in the post-operative period. The total rescue bolus doses required during study period was 8.79±7.39 μg in group N5 which was significantly higher than 4.35±5.08 μg in group N6. Conclusion: Study successfully demonstrates that to prevent spinal induced hypotension, the intravenous bolus dose of 6μg norepinephrine when co-administered with spinal anaesthesia was more effective than 5μg norepinephrine in terms of decreasing total rescue dose requirement of vasopressorand haemodynamic parameters.

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