Abstract

The subcutaneous administration of nitroglycerin is a straight forward and inexpensive technique that allows a high concentration and long persistence of the vasoactive agent at the spasm site level without entering the bloodstream significantly. Objectives:Aim of this study to compare the effect of subcutaneous infiltration of nitroglycerine-lignocaine combination versus Lignocaine alone for facilitating radial artery cannulation Methods:This was a randomized controlled study. A total of 104 patients were enrolled, all the participants were allocated randomly into two groups:. Group LN (n=52): received subcutaneous injection of Nitroglycerin 100 µg (o.2ml)-Lignocaine (0.8ml) 2%. Group L (n=52): received subcutaneous injection of 2% Lignocaine (1ml) Patient age, body weight, height, BMI and baseline vital parameters were recorded. History regarding previous surgery, Anaesthesia, significant comorbities, medications and radial artery diameter before and after infiltration were recorded. Results:Mean age and BMI in LN group was 44.0 ± 11.48 and 24.66 ± 2.74, 41.1% were males in LN group while 63.5% were males in L group. There is no statistical significant difference in terms of age, gender, BMI, co morbidities, ASA status and hemodynamic parameters. Radial artery catheterisation in the first attempt was 68.6% in LN group and 30.8% in L group, statistically significant (p<0.05). The palpability pulse index was better in nitroglycerine-lignocaine group compared to lignocaine group. The results are statistically significant (p<0.05). Conclusion:Subcutaneous infiltration of nitroglycerin-lignocaine before radial artery cannulation improved the first-attempt success rate and reduced the overall complication rates

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