Abstract

The aim of the study was to compare the effectiveness of atracurium 0.5 (2 ED95) mg/kg IV versus two different doses of cisatracurium, i.e., 0.1 (2 ED95) and 0.15 (3 ED95) mg/kg IV for intubation with regard to onset time for intubation, intubating conditions, duration of blockade, and hemodynamic parameters. Material & methods: A Prospective, randomized, single blinded study was conducted in the Department of Anaesthesiology in Chengalpattu medical college and hospital on patients undergoing surgery under General anaesthesia in between the duration of JUNE 2018-MAY 2019. 60 patients of ASA PS I and II were taken for the study. Institutional ethical committee approval was obtained. Permission from collaborating department was also obtained. The procedure was explained to the patient in their own mother tongue and written informed consent obtained. Results: There were more number of female patients in group 1 and 2 and more number of male patients in group 3. The age difference among the groups was not statistically significant (p>0.05). There was no significant difference between group 1 and 3(p>0.05) in jaw relaxation, vocal cord position and response to intubation. Heart rate, SBP and DBP were gradually returned to baseline at 5 minutes and may be due to stress response and was not statistically significant. Conclusion: Cisatracurium 0.15 mg/kg provides excellent intubating conditions with rapid onset of action, with longer duration of action and no significant hemodynamic changes when compared with cisatracurium 0.1 mg/kg and atracurium 0.5 mg/kg and hence cisatracurium 0.15 mg/kg can be used as an ideal non-depolarizing muscle relaxant for intubation.

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