Abstract

Laparoscopic cholecystectomy (LC) requires the creation of pneumoperitoneum via insufflations of carbon dioxide; resulting in increased partial pressure of carbon dioxide (Co2) and intraperitoneal pressure which leads to changes in pulmonary functions and hemodynamic measurements. Liver function indicators were observed to be disrupted after a laparoscopic cholecystectomy (LC) in numerous studies. Pneumoperitoneum induced by carbon dioxide modifies splanchnic microcirculation and can affect lung, liver, kidney and heart physiology. The purpose of the study was to determine how liver function tests in LC were affected by carbon dioxide pneumoperitoneum. The studies objective was to determine the impact of changes to liver function test and the safety of the surgery. Methods of study: Pre operative and post operative ( day 1 and day 3 ) serum bilirubin, albumin, AST and ALT will be estimated ( Method used for serum Bilirubin and albumin is Colorimetric and for serum AST and ALT is multiple – point rate ) followed by Comparison of preoperative and postoperative liver enzymes changes in laparascopic cholecystectomy with CO2 as pneumoperitoneum . Results : There is statistically insignificant changes of serum bilirubin and albumin on post operative 3 rd day in both open and laparoscopic cholecystectomy but in case of laparoscopic cholecystectomy there is statistically significant change of serum ALT in post operative day 1 and 3 with p value <0.001 and statistically significant elevation of serum AST on post operative day 1 whereas on post operative day 3 it is statistically insignificant with p value <0.001. In terms of duration of hospital stay and duration of surgery longer duration is found in open cholecystectomy as compared to laparoscopic cholecystectomy .Discussion: Current study shows no change in serum bilirubin and albumin but shows statistically significant increase of serum AST and ALT in post operative status of laparoscopic cholecystectomy

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