ISSN 0975-3583

Journal of Cardiovascular Disease Research

    A Comparative Study of Prophylactic Ondansetron Versus Palonosetron for Post Operative Nausea and Vomiting in Patients Undergoing Major Surgeries under General Anaesthesia

    Dr. Archana S. Mhatre, Dr. Nehal Chandra, Dr. Bethan Olive Varughese, Dr. Priyanka Guruprasad Cavale
    JCDR. 2024: 111-118


    Background Postoperative nausea and vomiting (PONV) a typical side effect of major operations, can unexpectedly postpone hospital discharge. The present study was done to compare prophylactic Inj Ondansetron 4 mg IV versus Inj. Palonosetron 0.075mg IV for post operative nausea and vomiting in major surgery. Methods The present study was done in department of Anaesthesia at Terna Hospital and Research Centre. After approval from ethical committee 60 patients undergoing major surgeries under GA were studied during the period of one year. Patients were allocated into two groups with 30 patients in each group. The statistical program SPSS 25.0 was used to analyse the data statistically. Results The mean age of patients in both groups was between 40 to 50 years. Female patients (13/17) were higher in group P and male patients (17/13) were higher in group O. The results were significant for comparison at 24 to 48 hours for PONV and VAS. Group O there was no need of rescue antiemetic where as in group P it was done between 0 to 6 hrs. for 1 patient and 6 to 24 hrs. for 1 patient.


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    Volume & Issue

    Volume 15 Issue 6