Abstract

To compare the effects of combination of sitagliptin + Metformin vs Sitagliptin alone on paramaters such as Body mass index, HDL-C & Triglyceride levels in recently diagnosed patients of type 2 Diabetes mellitus. Methods: This is a cross-sectional study which includes evaluation of body mass indices and biochemical parameters of 50 patients divided in 2 groups of 25 subjects in each group. Group 1 is Sitagliptin only group (100 mgs given in two divided dose of 50 mg each orally) and Group 2 is Metformin 1000 mg + Sitagliptin 50 mg given twice a day . Their body weight (BMI) were calculated & and biochemical parameters pertaining to lipid profile 1) HDL choleterol & 2) serum Triglycerides were measured and findings were recdorded at base line and in each follow-up. Z test is used for statistical analysis. Results: Results are reported as either statistically significant or not .From 24th week onwards there was statistically significant reduction in BMI in both the groups more so of in the Group 2 (Combination group) where the reduction in BMI was highly significant (p<0.001). The HDL choleterol level showed an increment which was significant in both the groups in group 2 it was highly significant (p<0.001). Triglyceride levels in Sitagliptin alone group showed significant reduction whereas sitagliptin + metformin combination group showed slight increase in triglyceride levels the difference was significant. Conclusions: In conclusion, significant differences was found in body mass index, HDL cholesterol levels and serum triglyceride levels in type 2 DM patients treated either with sitagliptin alone or in combination with metformin. Furthermore the reduction in body mass index and elevation in levels of HDL cholesterol were more in Combination drug treatment group as compared to sitagliptin alone

Description