Abstract

In present study we aimed to compare the levels of advanced oxidation products of proteins, magnesium, zinc, and uric acid in blood and urine between type 2 diabetics with nephropathy, those without problems, and normal healthy controls. Additionally, this study focused on the relationship between serum and urine levels of advanced oxidation products of proteins, magnesium, zinc, and uric acid in type 2 diabetic patients with nephropathy and diabetic patients without nephropathy, as well as the relationship between these levels and microalbuminuria and glycated haemoglobin. Methodology: This study involved 90 participants, of whom 30 had diabetes without complications, 30 had diabetes with nephropathy, and 30 were otherwise healthy people. Standard spectrophotometric techniques were used to measure the amounts of Zn, Mg, and uric acid in the serum and urine of AOPP patients. Results: When compared to diabetic patients and healthy controls, the levels of serum AOPP, Uric acid, and Zn and Mg were higher in patients with diabetic nephropathy. Zn and Mg are excreted in higher and more noticeable amounts through the urine. Although not statistically significant, there was a positive correlation between S AOPP and MAU and a negative correlation between S AOPP and S Zn and S Mg. It was statistically significant that s-uronic acid and MAU had a favourable connection. Conclusion: In diabetic individuals with or without nephropathy, the current study found substantial alterations in AOPP, Zn, Mg, and uric acid. Compared to diabetics without problems, those with diabetic nephropathy had more significant alterations in these indicators. In addition to microalbuminuria, serum trace element levels may be used as diagnostic indicators of diabetic nephropathy.

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