Abstract

Thyroid disorders stand as prevalent endocrine maladies on a global scale. In orchestrating the synthesis, metabolism, and mobilization of lipids, thyroid hormones assume a pivotal role. Evidently, deviations in thyroid function may impart modifications upon circulating lipid levels. The principal objective of this investigation was to elucidate the nuances of lipid level perturbations associated with thyroid dysfunction. Material and Methods: This study adopted a cross-sectional observational design. The cohort under scrutiny encompassed 30 individuals afflicted with hypothyroidism, an equal number beset by hyperthyroidism, alongside 30 euthyroid counterparts. Through estimation and subsequent juxtaposition, levels of total cholesterol, triglycerides, high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and the LDL/HDL ratio were meticulously scrutinized. Results: Within the hypothyroidism stratum, a discernible elevation materialized in total cholesterol, LDL-C, and triglyceride levels, accompanied by a concomitant reduction in HDL-C concentrations. Conversely, hyperthyroidism heralded a statistically significant reduction across total cholesterol, triglyceride, LDL, VLDL levels, along with a diminished LDL/HDL ratio. Conclusion: Aberrations in thyroid function wield the potential to exert profound modifications upon the lipid profile. It is noteworthy that hypothyroidism emerges as a notable risk factor for cardiovascular ailments. In light of this, the systematic inclusion of thyroid hormone evaluation within routine screening protocols assumes paramount importance, offering a window for timely intervention and management of cardiac ailments precipitated by thyroid dysfunction.

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