Abstract

BACKGROUND Proteinuria is common in patients with chronic kidney disease, however the relationship between proteinuria in Chronic Kidney Disease (CKD) and thyroid function remains unclear. Hence the objective of this study was to explore the association between thyroid dysfunction and albuminuria in CKD patients. MATERIALS AND METHODS A hospital based study was conducted among 185 CKD patients between January 2023 and January 2024. The stage of CKD was determined based on the eGFR values. Albuminuria was classified as mild, moderate and severe based on the albumin creatinine ratio (ACR). To evaluate the thyroid functions, TSH, Free T3, Free T4 were measured. RESULTS Among the study population, 40% had Type 2 Diabetes Mellitus, 22.70% had nephrosclerosis, 18.9% had Glomerulonephritis and 61.62% were on antihypertensive medication. Albuminuria was categorized as mild in 86(46.49%) cases, moderate in 62(33.51%), and severe in 37(20%). There was a negative association between albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate. 40 (21.62%) patients had hypothyroidism. There was a positive correlation between FT4 and ACR but no relationship between FT3 or TSH with ACR. Hypothyroidism and Euthyroid sick syndrome was more common in all groups of ACR than hyperthyroidism.

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