Abstract

Globally each year, 5-7% of pregnancies are preeclampsia affected resulting approximately 70,000 maternal and 500,000 fetal deaths. Preeclampsia adversely affects the mother and fetus causing some severe complications including fetal growth restriction (FGR), preterm delivery and perinatal death whereas, maternal complications are linked to hypertension, acute kidney damage, stroke, cardiomyopathy, liver failure, pulmonary edema and death.There are various risk factors for preeclampsia such as previous history of preeclampsia, nulliparity, obesity, chronic hypertension, older age and diabetes mellitus. Preeclampsia is specified by increased arterial blood pressure and proteinuria, whereas, eclampsia is characterized by convulsion, coma or both in preeclamptic patients. Aim & Objective: 1. A descriptive study of biochemical changes as a predictor of severity of preeclampsia and associated maternal and fetal outcome at teritiary care centre.2. To study the maternal and fetal outcome. Method: Study design: Prospective study. Study setting: Department of OBGY Rohilkhand Medical College And Hospital Bareilly. Study duration: 1 year from November 2022 to August 2023. Study population: All patients coming to our institute during study period according to exclusion and inclusion criteria. Sample size: 100. Results: Majority of study participants were from 26-30 years age group e.g. 30 followed by 21-25,18-20,31-35 and > 35 years age group,29,18,16 and 7 cases respectively. most of the study subjects were primiparous contributing 72 (72%) and 28 (28%) were multipara. majority of subjects delivered through NVD 59,followed by LSCS 26 and AD 15 cases. normal live births were seen in 63 (63%) cases followed by Prematurity 17%, RDS 15%, Early neonatal death 3% and Still birth in 2 cases respectively. Conclusions: The current study findings suggest that serum ALT, ALP, total proteins and albumin levels were significantly different between mild and severe groups of preeclampsia, and these biochemical markers can be utilized to predict and assess the severity of preeclampsia.

Description