Abstract

Laryngoscopy and endotracheal intubation have been the mainstay in providing adequate airway management and anesthesia delivery. Hemodynamic response to laryngoscopy and endotracheal intubation is a sympathetic response,1 which may be the result of an increase in catecholamine activity. Attempts were made by various investigators to reduce the sympathetic response to laryngoscopy and intubation. Methodology- The study was conducted in the Anesthesiology department, at the tertiary care hospital for a period of 18 months. 90 patients aged between 18 years to 60 years of ASA Class 1 and 2, posted for elective surgeries under general anaesthesia. 90 normotensive adult patients, after informed consent divided randomly into 3 groups of 30 patients. Group C patients were given the 2 placebo capsules orally one hour prior to induction. Group P75 patients were given 75mg pregabalin capsule and one placebo capsule orally one hour prior to induction. Group P150 patients were given two 75mg pregabalin capsules orally one hour prior to induction. Randomisation of the group was done using shuffled sealed opaque envelope method. Heart rate, Systolic Blood pressure, Diastolic Blood Pressure and Mean Arterial Pressure recordings were done along with sedation scoring (using Ramsay’s Sedation Score). Results: There was a significant increase in heart rate in the control group as compared to the P75 and P150 group. In the P75 Group, there was a statistically significant increase in heart rate as compared to the P150 group at first minute after laryngoscopy. In the P150 Group there was a statistically significant fall in SBP, DBP and MAP as compared to the other two groups at various time intervals which was statistically significant. Also there was a statistically significant decrease in Propofol and Vecuronium dose requirement in both P75 and P150 group as compared to the control group. Conclusion: Pregabalin 150mg is more effective than Pregabalin 75mg in suppressing the haemodynamic response. The requirement of Propofol for induction and requirement of Vecuronium for muscle relaxation, are decreased by oral premedication of Pregabalin. There is no effect of Pregabalin when given as a premedicant on the recovery status and level of sedation after general anaesthesia.

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