Abstract

The aim of the present study was to compare the efficacy of prophylactic granisetron on postanaesthetic shivering in comparison to pethidine. Methods: The present study was conducted in the Department of Anaesthesia and we selected 200 patients aged 20–50 year, American Society of Anesthesiologist (ASA) physical Status I and II, scheduled for lower abdominal surgery under spinal anaesthesia. The patients were randomly allocated to Group P (n = 100) receiving pethidine 0.4 mg/kg and Group G (n = 100) receiving granisetron 40 mcg/kg intravenous (IV) as study drug before spinal anesthesia. Results: The three groups had similar characteristics in terms of age, weight, height, gender, length of anaesthesia, duration of surgery, and ASA physical state. The incidence of postoperative shivering upon arrival in the recovery room, 15 minutes after arrival, was lower in Group G than Group P, which was not statistically significant (p>0.05). However, in Group G and Group P, 4 and 10 patients, respectively, had grade 3 shivering. Nevertheless, there were no notable disparities in the central body temperature among the patients before to and during the administration of anaesthesia. Conclusion: Prophylactic administration of granisetron at a dosage of 40 mcg/kg intravenously is as effective as pethidine at a dosage of 0.4 mg/kg in preventing shivering after spinal anaesthesia during surgery. Additionally, granisetron helps maintain higher levels of core temperature and oxygen saturation compared to pethidine. Prophylactic use of granisetron also decreases the need for antiemetic medications.

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