Abstract

The aim of the study to identify and analyze ADRs in post-operative orthopedic patients receiving analgesics and to determine the causality and safety profile of all the prescribed medications Methods: A prospective study was carried out in orthopedic department and total 196 patients fulfilling the inclusion criteria were enrolled in this study to observe the risk of adverse drug reactions (ADRs) due to Analgesics. All the ADRs were further analyzed in relation to age and sex, type of drug and its pattern, incidence, frequency, severity and causality Results: Out of 196 patients, ADR is seen in 56 patients receiving analgesics. Most common reported ADR was constipation (53.5%) followed by gastritis (26/7%) and dizziness (10.7%). The suspected ADRs were assessed for their causality, it was revealed that 15 were probable and 41 were possible as per WHO Scale. Conclusions: Analgesics are prescribed most commonly for post-operative control of pain and inflammation; therefore, active pharmacovigilance should be carried out so it will allow treating physician to identify the ADR associated with drugs which are commonly prescribed by the physicians which will in long term provide beneficial effect to patients.

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