Abstract

The aim of the present study was to compare the efficacy of intralesional triamcinolone, intralesional 5- FU and combination of triamcinolone with 5-FU in treatment of keloids. Methods: The study was carried out on patients with keloid attending OPD of Department of Skin, V.D. and Leprosy, B. R. D. Medical College, Gorakhpur. Male and Female patients of 18 to 50 years of age with keloid to give consent for treatment were included. We took 60 patients for the study who were willing for the treatment after taking well informed consent from the patient. Results: Male and female in group A and C are 50% each and in group B there are 70% males and 30% females. 47% of patients belonged to age group of 18- 30, 40% in age group of 31-40 and 13 % over 41 years. among study groups with 74% patients having keloid on chest and 16 % on back and 10% on arm. Among study groups where in traumatic etiology was more common with 70% of patients in group A, 50% patients in group B and 60% patients in group C followed by spontaneous and infective etiology. 2 patients from group B and group C having positive family history positive. Pigmentation grading according to vancouver scar scale with mean baseline value of group A, B and C as 1.60±0.55, 1.60±0.55 and 1.60±0.52 improving to 0.20±0.39, 1.2±0.31and 0.40±0.82 respectively after 24 weeks. In Group A telengiectasia, skin atrophy and hypopigmentation was seen whereas ulceration and pain was more common in Group B. There were no systemic side effects. Conclusion: In our study the prevalence of keloids was found to be more in males than females. The majority of keloids were seen in the 18 to 40 years age group in our study. Etiology was divided into “infective,” “traumatic,” and, if there was no discernible etiology, “spontaneous. The maximum number (56%) of patients had traumatic etiology for development of keloids in our study. The other common etiology observed was spontaneous and infective in the descending order of frequency.

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