ISSN 0975-3583

Journal of Cardiovascular Disease Research

    A prospective observational study on foeto-maternal outcome in patients with intrahepatic cholestasis of pregnancy treated with ursodeoxycholic acid

    Dr Jayasree Hansda, Dr. Nazira Khatun, Dr. Animesh Naskar, Dr Kajal Kumar Patra, Dr Tapan Mandal
    JCDR. 2023: 584-597


    Intrahepatic cholestasis of pregnancy (ICP), characterised by elevated serum bile acid concentrations or elevated aminotransferase levels with pruritus, usually develops during the late second or third trimester and rapidly regresses after childbirth. The etiology of ICP is not yet completely understood, but it probably depends on the genetic predisposition, hormonal and environmental factors. IC is the most common liver disease specific to pregnancy. Methods: This study was a Prospective Observational Case Control Study conducted in the Department of Obstetrics & Gynaecology, Burdwan Medical College & Hospital, Burdwan, West Bengal, India from January 2019 to June 2020. 50 pregnant women with ICP cases treated with UDCA were included in the study. A suitable predesigned pretested Proforma for data collection was used. Template was generated in MS excel sheet and analysis was done on SPSS software. Results: Among 50 ICP cases treated with UDCA 78% pruritis resolved, 28% of ICP not treated with UDCA pruritis resolved. among 50 cases 8 patients had preterm labour (16%), 4 patients had PPROM (8%), 9 patients had PROM (18%), 18 patients had oligohydramnios (36%), 2 patients had post dated pregnancy (4%),1 patient had post term pregnancy (2%), 3 babies had IUGR (6%). 12 neonates required admission to SNCU (24%). There were 2 intrauterine foetal deaths (4%), 1 congenital anomaly (2%). There were 5 perinatal deaths among cases. Among these 50 babies, 1 baby was VLBW (2%), 17 babies were LBW (34%) and 32 babies had normal birth weight >2.5kgs (64%) and none was XLBW. Among 50 cases ICP treated with UDCA, 20 patients (40%) post-partum resolution happened at 2 weeks and 50 patients (100%) resolution happened at 4 weeks. Conclusions: Intrahepatic cholestasis of pregnancy has adverse maternal, foetal and neonatal outcome. There was significant resolution of the pruritus after 3 weeks of treatment with UDCA of ICP patient


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