Abstract

Leprosy also known as Hansen’s disease, still continues to be an important public health problem. This entity expresses a wide array of clinical and pathological manifestations depending on the immune response of the patient. Clinico-histopathological examination and their correlation in different spectrum of disease assumes a pivotal role in early diagnosis and better management of the patient. Objectives: To study the clinico- histopathological correlation in various types of leprosy and confirm clinically proven leprosy patients by histopathological examination. Material and Methods: The study was conducted at the Department of Pathology, Gajra Raja Medical College and J.A group of hospitals, Gwalior (M.P) for a period of 18 months from January 2021 to June 2022. Cases of all age groups were included. A total of 50 new cases of leprosy were selected on clinical ground attending dermatology OPD. Then these patients were subjected to skin biopsy. Histopathological diagnosis was done on the basis of Ridley Jopling Classification and then it was correlated with the clinical classification to evaluate the concordance among two. Results: The present study comprised of 50 patients, of which 38 were males and 12 were females. Majority of the patients were between 21- 40 years of age. Both clinically and histopathologically, Borderline tuberculoid constituted the predominant group 46% and 48% respectively. The overall Clinico-histopathological correlation was seen in 37 cases(74%). Maximum correlation was found in LL followed by BT patients. Conclusion: Cumulative clinical and histopathological diagnosis help in accurate typing of leprosy, thus facilitating appropriate therapy to prevent complications

Description