Abstract

Introduction: Ketamine and propofol are two anaesthetic commonly used for intravenous anaesthesia, in day care procedures, as they have desired characteristics like rapid induction and rapid recovery. Ketamine and propofol combination in 1:1 ratio is termed as ketofol, which has several advantages, due to their opposing physiologic effects. The present study was done to understand, whether ketofol is superior to propofol alone, and to assess their side effects. Material and methods: Prospective study, was done in 100 adult patients between, with ASA grade I and II, scheduled for day care surgeries in a hospital. Institutional ethical committee clearance and informed consent from patients were obtained. Patients were divided into two groups of 50 each and were administered total intravenous anaesthesia with ketofol or propofol alone, after premedication: Group A: received ketofol Group B: received Propofol alone. Continuous monitoring of patients in either group was done during induction, intra-op and in post operative recovery room for 1 hour. Induction, Time to loss of eye lash reflex, Time for incision, total drug used, adverse Events, hemodynamic changes, PONV, return of airway reflex, recovery time, VAS Score, recovery scale (using Modified Aldrete Scale) were recorded. Independent sample t test and chi-quare test was used, with P<0.05 as statistically significant. Results: Conclusions: The combination of propofol and ketamine has several benefits because of hemodynamic stability, lack of respiratory depression, good recovery and potent post-procedural analgesia.

Description