Abstract

Rocuronium is a monoquaternary amino steroid nondepolarizing neuromuscular blocking drug with rapid onset, intermediate duration of action and widely used when succinylcholine is considered undesirable or contraindicated for rapid sequence intubation. The current study aims to compare three multiples of ED95 doses of rocuronium 2xED95(0.6mg/kg), 3x ED95(0.9 mg/kg) and 4x ED95 (1.2mg/kg) in terms of their intubating conditions at the end of 60 sec and their duration of action in patients undergoing elective surgeries under general anaesthesia. Methodology: After our Hospital Research and Ethics Committee approval and obtaining informed written consent, 90 ASA physical status I or II patients scheduled for elective surgeries under general anesthesia were included in this prospective, randomized, comparative study. The patients were randomly assigned into three groups of 30 patients each, to receive one of the three doses 0.6 mg/kg, 0.9 mg/kg or 1.2 mg/kg of rocuronium. Intubation was performed 60 sec later and intubating conditions were assessed using coopers scoring system including the parameters jaw relaxation, vocal cord condition and response to intubation. In addition vocal cord position and movement of limbs during intubation were also assessed. Continuous TOF monitoring is initiated after induction and the time to recovery of 25% of first twitch of TOF is determined to be the duration of action of the induction dose of rocuronium. Patients were monitored throughout the procedure for any adverse effects.

Description