Abstract

Hypertension is a known public health issue in India. Several studies have suggested that hyperuricemia and hypertension are related. Serum uric acid (UA), a standalone predictor for the development of hypertension. The onset of hypertension is frequently predicted by an elevated uric acid level. This present study was a hospital-based case control study carried out in the Department of Medicine at Teerthanker Mahaveer Medical College and Research Centre, Moradabad (U.P.) to study the association of hyperuricemia with hypertension. Material and Methods: This study included an equal number of age and sex matched cases and controls. Subjects were divided into - Group 1 and Group 2.Group 1 comprised of cases of Primary hypertension. Group 2 comprised of normotensive subjects. Inclusion Criteria- Group 1 (Cases): Cases of Hypertension as per JNC VII guidelines. Group 2 (Controls): Subjects who were normotensive. Exclusion Criteria-Known cases of hyperuricemia/ gout, diabetes mellitus, renal failure, metabolic disorders, fluid volume disturbances and endocrinal disorders, Smokers and chronic alcoholics, H/O recent intake of ATT {in last 6 months}, Chemotherapy/Radiotherapy. Results: Majority of study subjects (66%) of study subjects were above 30 years of age. 50% were males while 50% were females. 34% cases in hypertensive Group 1 had past history of hypertension,7% cases in hypertensive Group 1 had history of chest pain 7% cases had breathlessness 5% cases had sweating associated with chest pain. 37% were in Stage 1 as per JNC VII guidelines while 11% in Stage 2 and 2% in prehypertension category. Raised uric acid levels were seen in 27% of cases of which 19% were in hypertensive Group I and 8% in normotensive Group II. This difference was found to be statistically significant (p<0.05). Conclusion: The findings of the current investigation suggest that hyperuricemia may also be an independent risk factor for the onset of hypertension in addition to being a marker of CVDs.

Description

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