Abstract

Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. Aim and Objective: To study of biochemical marker of oxidative stress in Acne vulgaris patients. Method: 25 acne patients and 25 healthy people were selected and their serum levels of superoxide dismutase SOD and Malondialdehyde MDA were estimated and the results are compared with the control group. Also, the relationship between the duration and severity of acne with the parameters is assessed. Result: The activity of SOD is found to be decreased and the level of MDA is found to be increased in acne patients compared to healthy people, suggesting increased oxidative stress in Acne vulgaris patients. Conclusion: The stronger response observed in serum samples from patients with higher GAGS scores suggests that markers of oxidative stress may be useful in evaluating the progression of acne and in elucidating the mechanisms of disease pathogenesis.

Description