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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    A Study of COL1A1 Genotype and Bone Marrow Density (BMD) in Osteoporosis in Indian Women- A Systematic Review


    Dr. Sowmya S., Dr. Meenakshi Parthasarthy, Dr. Abhijit Patil, Kotakonda Priyanka
    JCDR. 2024: 1351-1357

    Abstract

    Osteoporosis, characterized by increased fracture risk and reduced bone mass, is often linked to genetic factors such as mutations in the COL1A1 gene, which encodes the α1(I) chain of type I collagen, a key bone protein. This systematic review investigates the relationship between COL1A1 polymorphisms and bone mineral density (BMD) in Indian women. Key polymorphisms of interest include the Sp1 binding sites -1997 G>T (rs1107946), 1663in/delT, and +1245 G>T (rs1800012). A comprehensive literature search was conducted in Google Scholar, PubMed, and Scopus, focusing on BMD and COL1A1 genetic data in this demographic. The review addresses ongoing debates about the strength of the link between COL1A1 polymorphisms and low BMD or increased fracture risk. Despite variations in study designs, the findings underscore COL1A1's role in osteoporosis susceptibility in Indian women and highlight the need for more research on genetic markers for targeted osteoporosis interventions.

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    Volume 15 Issue 5

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