Abstract

Psoriasis is a chronic, recurrent, inflammatory, and proliferative disease. It is associated with metabolic syndrome i.e. dyslipidemia, hypertension, obesity, cardiovascular diseases and insulin resistance. The high incidence of cardiovascular events in psoriasis is highly associated with abnormal lipid metabolism. Aim and objective: To measure the serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Material and method: This was a case-control, cross-sectional study. A total of 25 psoriatic patients and 25 healthy individuals were enrolled. This study was conducted at the outpatient department of dermatology in SBIMS, Raipur, India. The serum level of total cholesterol (TC), triglyceride (TG), very lowdensity lipoprotein cholesterol (VLDL-C), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A-I and apolipoprotein B were measured. Result: The results were compared between psoriasis patients and healthy controls by using ‘Z’ test. Serum total cholesterol, triglyceride, low density lipoprotein were significantly increased in psoriasis patients as compared to control group. But serum High density lipoprotein were significantly decrease in Psoriasis patients compared with controls. Conclusion:This rise in lipid levels and decreased High density lipoprotein fraction is an alarming sign that psoriasis is progressing towards Cardiovascular risk.Therefore, controling the lipid fractions and early mangement can save psoriasis patients from cardiovascular risk

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