Abstract

Background: Worldwide coronary artery disease is the leading cause of death and reduction in Disability Adjusted Life Years. Only a few studies of the association of epicardial adipose tissue (EAT) with the complexity of CAD have been there, therefore, this study was planned to calculate the anterior EAT thickness by 2D echocardiography, and to determine the severity of coronary lesion by syntax score (SS) on coronary angiogram. Methodology: This hospital-based observational study was carried out with total 100 patients with a diagnosis of CSAP got admitted in the department from August 2022 to July 2023 at a tertiary care facility. Patients of >18 years of age, who gave informed consent, diagnosed with CSAP undergoing coronary angiography were included in our study. The concentrations of triglycerides (TGs), total cholesterol, HDL, VLDL was measured, and LDL was lab tested, and the Syntax score was calculated. Data analysis was done using SPSS version 23.0. Results: In our study, the mean age of patients was 54.34±14.87 years, with male to female ratio was 3.5:1. Dyslipidemia was the most common risk factor. High syntax score was seen in 42 cases, followed by intermediate in 31 and low score in 27 cases. Mean EAT score was more in cases with higher syntax score and this score was statistically significant (p<0.05). Patients with abnormal waist circumference have significantly higher syntax score (p<0.05). Cutoff of EAT was 6.15 using ROC, and for this cutoff sensitivity and specificity was 87.5% and 100% respectively. Conclusion: When comparing patients with an SS of ≥33 to those with an SS of <33, the EAT thickness in the former group was considerably larger. The 6.15 mm EAT threshold value was found to be predictive of severe CAD. A noteworthy association was seen between EAT and both WC and lipid profile.

Description