Abstract

Several theoretical procedures have been proposed to elucidate the mechanisms by which elevated levels of homocysteine contribute to the development of venous thrombosis and atherosclerosis. One of the several possibilities posits that homocysteine exerts a deleterious effect on the arterial endothelium, hence initiating the process of clot formation. Another mechanism postulated is that when methionine metabolism is faulty, there is aberrant methylation of the DNA and cell membranes. The condition of hyperhomocysteinemia has been seen to interfere with the normal functioning of the methionine metabolic pathway. Furthermore, it has been emphasised that individuals with atypical levels of vitamin B12, B6, and folic acid have elevated concentrations of homocysteine, resulting in vascular endothelial alterations. The thrombotic risk associated with hyperhomocysteinemia of various aetiologies remains uncertain. The objective of this study is to investigate the correlation between blood homocysteine levels and the risk of venous thrombosis.

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