Abstract

Breast lesions are a wide variety of lesions made up of many distinct entities, each with their own special characteristics. Early evaluation of lesions and rapid, precise diagnosis can lessen patients' anxiety and may even save their lives. The most common cancer among Indian women is breast cancer, which affects 25.8 per 100,000 women. Less than 0.1% of breast carcinomas are neuroendorine carcinomas. Neuroendocrine neoplasms (Br-NENs) of the breast are tumours in which >90% of cells exhibit histological evidence of NE differentiation, including NETs (low-grade neuroendocrine tumours) and NEC (high-grade neuroendocrine carcinoma). This definition was given in the most recent World Health Organisation (WHO) classification in 2018. Materials and Methods: Around 250 cases of breast lesions, both neoplastic and non-neoplastic, were referred to the pathology department at MAMS, Bachupally, Hyderabad, between June 2019 and June 2022. Ten of them had neuroendocrine cancer, it was discovered. The specimens were preserved with 10% formalin. Haematoxylin and eosin was used to stain the sample material in sections, after which some of the sections were examined under a microscope. Immunohistochemistry was carried out in these cases for the ER, PR, Her2neu, Synaptophysin, Chromogranin, and NSE. Results: Out of the 10 neuroendocrine cases, one instance of IDC (invasive ductal carcinoma) with localised mucinous areas and neuroendocrine differentiation was documented in addition to the nine Trucut samples that were identified as infiltrating duct carcinomas. The histology slides of the breast excision specimens from eight of the patients revealed cell clusters arranged in sheets and small nests segmented by thin fibrous septae. Trabeculae and rosettes were seen in two instances. A DCIS component was found in two instances. Infiltration into fat was seen in five of the incidents. Mucin pools were a case in point. Eight specimens were progesterone receptor (PR) positive, six were ER positive, and five of the ten were Her2neu positive. Synaptophysin, chromogranin, and NSE were all detected in 4 out of 10 instances, 7 out of 10 cases, and 9 out of 10 cases, respectively, in the cancer cells

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