Abstract

In this study, we wanted to evaluate the prevalence and clinical significance of low T3 in non-dialysis patients with chronic kidney disease. Material and Methods: This was a hospital-based observational, cross-sectional study conducted among 50 patients who presented with chronic kidney disease on conservative therapy, to Institute of Internal Medicine, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, for 6 months, after obtaining clearance from the institutional ethics committee, and written informed consent from the study participants. Results: The mean value of T3 in stage 5 and stage 4 CKD was lower than the mean value of T3 in stage 3 depicting a linear correlation between low T3 and the severity of CKD. In patients with non-dialysis CKD, thyroid dysfunction was very common accounting for about 68%. In the prevalence of low T3 in non-dialysis CKD patients, low T3 was present in 29 patients accounting for 58%. In the prevalence of low T3 syndrome in CKD patients, 26 (52%) patients had low T3 values. Conclusion: Low T3 syndrome was seen in 32% and low T4 syndrome was seen in 8% of patients. Low T3 syndrome was common in older patients with CKD. The lower the eGFR, the lower is the T3 value. Significance is that as the disease severity increases, the T3 values fall progressively depicting a direct relation between eGFR and T3.

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