Abstract

To ascertain the variations in serum aminotransferase levels in severe dengue, dengue fever with warning signals, and dengue fever without warning signs and to assess the relationship between serum aminotransferase levels and dengue illness severity. Materials and Methods: A co relational study was done on all the patients operated from 2020 to 2021 at Department of General medicine, Government General Hospital, Kurnool to investigate NS1Ag and Dengue IgM, IgG SEROLOGY, Hemogram- Hb, TLC, DLC, Platelet Counts, Hematocrit, Serum Electrolytes and Renal Function Test, Serum bilirubin, AST, ALT, ALP, USG abdomen Results: 12 patients with increased liver enzyme levels exhibited bleeding tendencies. In our study, 13 patients exhibited hepatomegaly. A USG abdomen revealed free fluid in 30 individuals. There was no statistically significant relationship between increased liver enzymes and free fluid. Overall, 23 individuals had elevated liver enzymes. Twelve patients with bleeding tendencies, thirteen patients with hepatomegaly, and twelve patients with free fluid on USG abdomen all had elevated liver enzymes. The mean AST and ALT concentrations in our study were 186.52 IU/L and 129.91 IU/L, respectively. Conclusion: In dengue fever, hepatic impairment is frequent. Either reactive hepatitis or direct viral damage to hepatocytes is the cause. In this study, elevated liver enzyme levels have prognostic value. Therefore, liver enzymes must be taken in order to check for problems and have predictive significance in dengue fever. Individuals with increased liver enzyme levels require more cautious monitoring than individuals with normal liver enzyme levels.

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