Abstract

In this study, we wanted to evaluate the serum high density lipoprotein (HDL) as a prognostic marker in sepsis. Material and Methods: This was a hospital based descriptive study conducted among 100 patients who presented with sepsis to the Institute of Internal Medicine, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, over a period of 6 months, after obtaining clearance from Institutional Ethics Committee and written informed consent from the study participants.Results: Hyperthermia was observed to be of 54% of study sample. Systolic BP less than 100 mmHg was observed in 53% of samples. Respiratory rate less than 22 was observed in 69% of samples. Patients without ventilator support were found to be 58%. 80% of samples were found to have low HDL levels. GCS, total count, platelet count, serum bilirubin, serum creatinine, acute physiology and chronic health evaluation (APACHE II) and sequential organ failure assessment (SOFA) scores were found to have significant correlation with HDL levels.Conclusion: Significant correlation was present between the patients with sepsis and serum HDL level. Low HDL values were observed in patients with severe sepsis and in those having severe organ dysfunction. Serial monitoring of patients with SOFA score, APACHE II score and HDL values are essential for better than a single value, for better prognostication and best clinical outcome in patients with sepsis.

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