Abstract

Chronic Kidney Disease (CKD) is a highly prevalent disease condition in India. There is a lack in knowledge regarding the genes associated with CKD in Indian Population. Aim: Hence, the present study is aimed to knock the association between IL-6 gene and progression of CKD in people of Andhra Pradesh. Materials & methods: This was a prospective observational study conducted for a period of 3 years. A total of 579 individuals were involved in the study and were divided into 3 groups i.e, group with early-stage CKD, latestage CKD and the control group. The general biochemical parameters were assessed and genotyping was done. All the obtained results were analysed statistically. Results: From the study results, it was found that CKD is more prevalent in men than in women in the study population. Blood urea and serum creatinine levels were high in late-stage CKD than in early and control groups. IL-6 gene was found to be significantly associated with CKD by giving p<0.005. Conclusion: To our knowledge, this was the first study to identify the gene association with CKD in Andhra population. The functional promotor IL6 C-572G(rs1800796) the only SNPs that affect IL-6 gene of CKD population in Andhra Pradesh.

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