Abstract

Clonazepam was used as a model medication for these objectives in order to examine the impact of polymers on the release mechanism of poorly soluble medicines from solid dispersions. Using polyethylene glycol 6000 (PEG-6000), Kollicoat IR, Kollidon VA 64, and Poloxomer in varying drug-tocarrier ratios (1:2, 1:4, 1:6, 1:8, 1:10), five distinct forms of solid dispersions were created. Solid dispersions were made using the solvent evaporation technique. In each dissolution basket for the pure drug and solid dispersions, 1000 cc of distilled water was used as the dissolving medium in an in-vitro dissolution investigation with a temperature of 37° C and a paddle technique at 100 rpm. The dissolution rate of pure Clonazepam was found to be very sluggish, but the dissolution rate of the solid dispersion was significantly increased. The medication's amorphous and crystalline fractions were presumably caused by its wettability and dispersibility. PEG-6000, Poloxomer, and Kollidon VA 64 (1:10 ratio) showed the greatest improvement in clonazepam's wettability and dissolving rate. When compared to pure clonazepam, solid dispersions including polymer (1:10 ratio) made by solvent technique shown a significant improvement in the release profile.

Description