Abstract

Elevation of serum ferritin levels leads to serious complications. increased serum ferritin levels lead to increased oxidative stress, further leading to inflammation, endothelial damage and consequently increasing the risk of hypertension. Aim: The aim of the present study was to estimate and compare serum ferritin levels in the hypertensive patients and control group. Methods: The present study was a hospital-based observational and analytical study. The study was conducted over a period of 1 year on 200 patients. The study group comprised of 100 patients (diagnosed with hypertension), and the control group comprised of 100 (age and gender matched) individuals. The levels of serum ferritin were analysed by the Sandwich ELISA method. Results: The results of the present study show that, the mean value of serum ferritin was 272.21±35.67 ng/ml in study group and 69.33 ± 28.12 ng/ml in control group. The mean SBP was 149.65±14.77 mm/Hg in study group and 106.12 ± 6.93 mm/Hg in control group. The mean DBP was 93.4± 9.12 mm/Hg in study group and 70.31±3.62 mm/Hg in control group. The results of the present study indicate that the difference between the mean serum ferritin and mean SBP, mean DBP among the study group and control group was found to be significant statistically (p=<0.05). Conclusion: The present study concluded that elevated serum ferritin level was significantly associated with the incidental risk for hypertension. This finding suggests the value of elevated ferritin level as an early predictor of hypertension.

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