Abstract

Organophosphate compounds are widely used as pesticides in the agricultural parts of the world. Nearly half of the admissions to emergency with acute poisoning are due to organophosphorus poisoning. Thus the treatment of organophosphorus compounds gained new dimensions with the help of ventilator support. This study predicts the factors which determine the need for Mechanical ventilation. Aim: This study aims to find the predictors for Mechanical ventilation in Organophosphates poisoning. Methods: 100 consecutive patients of organophosphorus poisoning above 18 years of age admitted at Government Dharmapuri Medical college were included in the study during the period of January 2021 to June 2022. It was a observational prospective study. Patients were selected by predetermined inclusion and exclusion criteria and were followed up during inpatient period. Statistical analysis used: SPSS statistical software programme was used for analysis. ‘p’ value <0.05 was considered as statistically significant. Results: In this study all of the patients who consumed parathion required ventilatory support. In the present study 78% of patients who consumed monocrotophos required ventilatory support. 77% of patients who presented with low GCS (3-7) required ventilator support in our study .80 percent of patients who had heart rate less than 60 required ventilator support. 91 percent of patients who presented with oxygen saturation of less than 90 % needed ventilator support. 77% of patients who got admitted after 4 hours of consumption required ventilatory support. Mean Cholinesterase level had was one of the important predictor in our study. All patients who required ventilator support had Mean cholinesterase level of 1353u/l. Conclusion: Parathion, monochrotophos consumption, poor GCS at admission, bradycardia and low oxygen saturation at admission, delayed presentation and low mean cholinesterase level are the important predictors of need for mechanical ventilation in Organophosphorus poisoning

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