Abstract

To evaluate the non-depolarising muscle relaxant rocuronium bromide being a substitute for succinylcholine chloride for endotracheal intubation without its adverse effects. Methodology: The study was conducted at ACSR Govt Medical College, Department of anaesthesiology, Nellore, Nellore District, Andhra Pradesh. The present study population consisted of 60 patients of ASA grade I and II were divided into two groups. Group R (n =30) was intubated with Rocuronium bromide 1.2 mg per kg body weight. Group S (n = 30) was intubated with Succinylcholine chloride 1.5 mg per kg body weight. In both the groups intubation was attempted at 60 s following injection of neuromuscular blocking drug. Observations were tabulated and analyzed using ‘students unpaired t-test’. Results: The demographic profile (age, gender, weight distribution) was comparable in both groups. The mean onset time of rocuronium bromide was 76.09±9.15 s and succinylcholine chloride was 56.13±3.76 s, the intubating conditions of both the groups were comparable. The duration of action of rocuronium bromide was 66.79±3.38 mins and succinylcholine chloride was 5.83±1.06 mins. The duration of action showed p value of <0.0001 which is highly significant. Haemodynamic parameters (HR, SBP, DBP, MAP) were comparable in both the groups. The present study shows that intubating conditions and onset time of rocuronium 1.2 mg per kg are comparable to those with succinylcholine mg per kg. However, the duration of action of rocuronium at this dose may present a clinical disadvantage, particularly in patients whose surgery is of short duration. Nonetheless, rocuronium may be a suitable alternative for succinylcholine particularly in patients who are at risk for the adverse sequalae of succinylcholine. Conclusion: Rocuronium bromide is a safe alternative to succinylcholine chloride in adult patients in situations where succinylcholine is contraindicated and in whom there is no anticipated difficult airway

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