Abstract

To determine the spectrum of thyroid abnormalities in both acute and chronic liver disease patients admitted to medical wards in ACSR Govt. General Hospital, Nellore Methodology: It was a cross-sectional study, a period of 18 months. Patients admitted to medical wards, ACSR Govt. General Hospital, Nellore. Results: In the present study, the mean age of Acute Liver Disease patients was 33.30 ± 11.17 and the mean age of chronic liver disease cases was 49.20 ± 12.75. Majority were male i.e. 80% and female were 20%. Among the chronic liver disease patients 4% had features of Hypothyroidism. 2% of Acute Liver disease patients had Encephalopathy and 20% had Icterus. Among chronic liver disease patients, 42% had Upper GI bleed, 205 had Encephalopathy, 58% had Ascites, 70% had Icterus and 52% had Edema. 38% of the study population had No ascites, 48% had Grade 1 Ascites out of which all had Chronic Liver disease and 14% had Grade 2 Ascites where 2% had Acute Liver Disease and 12% had Chronic Liver disease. Based on the grade of Encephalopathy, 14% had Grade 1 Encephalopathy out of which 2% had Acute Liver Disease and 12% had Chronic Liver Disease. Grade 2 Ascites were observed in 8% of the Chronic liver disease patients who had Grade 2 Encephalopathy. In the present study, Total Bilirubin and Direct Bilirubin had a statistically significant correlation observed with Thyroid profile as the p-value calculated to be <0.05. In the present study, a statistically significant Positive correlation was observed between AST, ALT, and Total T4 as the p-value was calculated to be <0.05. There was a decrease in Free T3 and Free T4 levels with an increase in severity and this finding was statistically significant as the p-value calculated to be <0.05. Conclusion: In the present study, Total Bilirubin and Direct Bilirubin had a statistically significant correlation observed with Thyroid profile, statistically significant Positive correlation was observed between AST, ALT, and Total T4 and Total Bilirubin was significantly correlated with Free T3, Free T4 and Total T3 and Direct Bilirubin was significantly Negative correlation was observed with Free T3, Free T4, and Total T3.

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