Abstract

Introduction- Thyroid hormone, namely thyroid releasing hormone, plays a critical role in maintaining cardiovascular system function, homeostasis and cardiac hemodynamics. This raises the risk of cardiovascular death, coronary artery disease, and hypertension. However, the relationship between abnormal thyroid function and cardiovascular consequences is still unclear. Thus, this study was done to look at any potential differences in thyroid profile in acute coronary syndromes. Material and method- The current study was a prospective cross-sectional hospital based study conducted on acute myocardial infarction (AMI) patients. After applying exclusion and inclusion criteria, a total of 200 AMI patients were enrolled with consent from all the participants. Following a 12-hour overnight fast, serum T3, T4 and TSH levels and other biochemical markers were measured using commercial kits. A complete data regarding demographical, clinical and physical examination along with electrocardiogram were noted. Statistical analysis was carried out by SPSS software considering p-value less than 0.05 as statistically significant. Result- The present study showed male dominance with 51-60years age group to be more prone to AMI in both the genders. There was a significant correlation between patients' age and gender with the incidence of AMI. The subclinical hypothyroidism (SCH) was observed in 16% and euthyroid was seen in 84% AMI patients. The most common comorbidity associated with AMI was hypertension along with STEMI as the major type of MI found in both SCH and euthyroid group. Males and age group 51-60years were seen to be more affected in both SCH and euthyroid group. The association between the demographic and clinical profile of AMI patients with the type of thyroid dysfunction was not significant.

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