Abstract

To evaluate the effect of combination of Metformin along with Sitagliptin on Body mass index, HDL-C & Triglyceride levels in recently diagnosed patients of type 2 Diabetes mellitus. Methods: This cross-sectional study includes analysis of total 25 patients receiving Metformin alongwith Sitagliptin as. Their body weight (BMI) & biochemical parameters namely HDL & Triglycerides were recorded at time of enrollment of paticipants and upon subsequent follow-ups. Results: After 24 week in patients receiving Sitagliptin 50 mg + Metformin 1000 mg in tablet form reduction in BMI was observed as compared to baseline values. Also the elevation in levels of serum HDL cholesterol was observed. The serum triglyceride levels showed variation as evident by observations recorded on 12th , 24th , and 36th week. Conclusions: Effects Sitagliptin 50 mg + Metformin 1000 mg taken twice a day as initial treatment in patients recently diagnosed with type 2 Diabetes mellitus was apparent as decrease BMI values, a rise serum HDL cholesterol which is considered good cholesterol whereas serum Triglyceride levels showed variations.

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