Abstract

The aim of the present study was to evaluate the microbiological profile in patients with perforation peritonitis with respect to anatomical site of perforation. Material & methods: A prospective observational cross-sectional study conducted from 2021 to 2022 where intraoperative peritoneal fluid sample in patients of perforation peritonitis was subjected to culture (aerobic and anaerobic) and sensitivity and results analysed with respect to anatomical site of perforation. Results: Out of total 100 patients, 49% were between 18-45 year of age group, 38% were between 46-65 year & 13 % were more than 65 years of age. Out of 100 patients, 76% were male and 24% were female. 43 patients had gastric perforation. 39 patients had ileal perforation. 6 patients had appendicular perforation. 6 patients had caecal perforation. 3 patients had jejunal perforation. 43 patients were positive for E.coli. 20 patients were positive for Klebsiella pneumonia. 8 patients were positive for Pseudomonas aeruginosa. 4 patients were positive for Candida albicans. 5 patients were positive for Acinetobacter spp. Conclusion: The predominant differential normal flora according to site of gastrointestinal tract was not reflected in the peritoneal fluid culture of patients with perforation peritonitis and E. coli was the most common organism isolated in all sites of perforation peritonitis. The antibiotic sensitivity profile showed the increasing resistance against third generation cephalosporins. Aminoglycosides, piperacillin and tazobactum, meropenem and colistin showed a significant antimicrobial activity against organisms isolated from cases of perforation peritonitis

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