Abstract

Human blood is a scarce and precious resource with no substitute. Blood and its components hold significant value as a crucial and valuable health resource. Blood transfusion is a vital therapeutic method that can be lifesaving in specific situations and is an irreplaceable means of clinical treatment. Aim: In light of the lack of a comprehensive systematic analysis on the rational utilization of blood in India, this systematic analysis was undertaken to address this significant issue of evaluation of clinical appropriateness of blood transfusion in India. Methods: The database search was carried out using PubMed, Medline, Embase, Scopus and Cochrane Library for the studies existing from the initial records till December 2022, that reported the incidence of inappropriateness of blood transfusion in India. After going through the databases, 1464 relevant articles were identified as per the search strategy. Among those 1308 duplicate records were taken away. Among the remaining one 166 records, 138 records were excluded majorly going through their titles and abstracts. Next matching our inclusion criteria and going through the full texts, 13 studies were excluded. Lastly, after excluding the reviews we included relevant 15 studies that reported clinical appropriateness of blood and blood products transfusion in India. All the included studies were published between years 2009-2022. Results: The rates of inappropriate use varied between 3.3% to 53%, depending on the specific type of blood component utilized. The highest rates of inappropriateness were found in cases involving Fresh frozen plasma (FFP), followed by Packed Red Blood Cells (PRBC). Conclusion: India faces challenges in ensuring the clinical appropriateness of blood transfusion, particularly regarding the use of plasma and red blood cells (RBCs). Inadequate dosing, lack of awareness regarding guidelines for blood component transfusion, and concerns about patient safety are the major contributing factors. Moving forward, it is crucial to implement comprehensive measures to enhance the clinical appropriateness of blood transfusions.

Description

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