Abstract

Metabolic syndrome is a cluster of metabolic abnormalities that has been related to an increased risk of cardiovascular disease and type 2 diabetes. Most people who have metabolic syndrome also suffer from additional metabolic disorders. These disorders include hypertension, abnormal lipid profiles, increased blood sugar, and insulin resistance. The goal of this study was to analyze the relationships between glucose, insulin, HOMA-IR (an estimate of insulin resistance), and lipids in people who had metabolic syndrome. Methods and components: All people included in the study agreed to take part. The "control group" consisted of 100 individuals of the same age and gender who were otherwise healthy. One hundred patients with metabolic syndrome were included in the second cohort. Normal-glycemic controls of the same age and sex were used as the non-metabolic syndrome group. Individuals in each group were classified as healthy if their BMI fell between 18.5-24.9 kg/m2, overweight if it was 25.2-29.9 kg/m2, and obese if it was 30 kg/m2. There was a statistically significant difference between the two groups in terms of fasting blood glucose (FBS), hemoglobin A1c (Hba1c), and insulin mean values. The average total cholesterol (TC) and triacylglycerols (TAGs) levels of patients with metabolic syndrome and healthy control subjects. Significant differences in serum weight measures across the groups were found. Mean TAGs levels in patients with metabolic syndrome were around 33 % higher than normal, which is still within the normal range. The molecular insights gained from such studies are highly desirable for helping doctors keep hyperglycemia under control and halt the development of associated disorders.

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