Abstract

Histopathological analysis of tissue sections continues to be the preferred and definitive diagnostic method. However, frozen sections serve a purpose in rapid intraoperative diagnosis and guides patient management during surgery. Aim: The objective of the research is to study a range of lesions by frozen section at different anatomical locations and determination of efficacy of frozen section in terms of accuracy, sensitivity, and specificity. Method: This is a retrospective study conducted at the Department of Pathology, SIMS, RC, Bangalore from November 2021 to November 2023.The analysis of frozen section was done followed by its comparision with subsequent histopathology reports. The overall Accuracy,Sensitivity and Specificity were calculated along with Positive predictive value and Negative predictive values. Results: The study involved 100 cases with 91 female and 9 male patients, aged between 17 and 80. Among the cases, 58 were gynecological, 7 were related to breast, 6 involved oral cavity margins, and 5 focused on sentinel lymph nodes. The overall accuracy of the study was 98.8%, with sensitivity and specificity rate at 98.8% and 92.8%, respectively. Additionally, the positive predictive value was determined as 98.8%, while the negative predictive value stood at 92.8%. Conclusion: Validity of frozen section analysis is confirmed by the study's results on specificity, sensitivity, and accuracy, which closely align with those of prior research. However continual refinement and larger prospective studies are required to enhance diagnostic accuracy and reliability across diverse pathological process.

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