Abstract

Electrolytes play a vital role in maintaining homeostasis in the body. Hyperkalemia and dysnatremia occurs most often in chronic renal failure due to compromised renal water regulation. Even in end stage renal failure hyperkalemia may lead to life threatening condition. There may be some secondary mechanisms apart from reduced renal function that could contribute to hyperkalemia in patients with Chronic renal failure. CKD patients are at additional risk of hyponatremia due to compromised capacity to dilute or concentrate urine. Furthermore, various drugs and limited nutritional solute intake can contribute to the Sodium derangements. Thus, in this study we aim to compare the sodium potassium derangement in Chronic renal failure patients grouped on the basis of Glomerular filtration rate (GFR). Study objectives 1. To evaluate the alteration of sodium potassium levels in Chronic Renal Failure patients. 2. Comparison of sodium potassium levels in different stages of Chronic Renal Failure patients. Study design Prospective Observational study Materials and methods This study was conducted at Shyam Shah Medical College, Rewa. Chronic Renal Failure patients were identified from the Medicine outdoor and indoor units. Results- 86.16 % patients were hyponatremic, 2.51 % patients were hypokalemic. There was a positive correlation between e GFR and sodium and negative correlation with potassium. Conclusion- Hyperkalemia is seen predominantly as compared to hyponatremia as CKD progresses from mild to severe form, most probably due to low numeric reference range of potassium. Attention of electrolyte levels is to be given not only in late stages of CKD, but also in early stages.

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