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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    An analysis of the QTc interval's predictive value in the occurrence of cardiac autonomic neuropathy in people with type 2 diabetes mellitus


    Dr. Lalitha Palaparthi, Dr. Surekha Kadamati, Dr. Purnima B Potharlanka, Dr. Rajesh Kumar Palaparthi
    JCDR. 2024: 1049-1052

    Abstract

    Background and Objective: To analyse the prevalence and possible factors contributing to (CAN) and evaluate the efficacy of extending the corrected QT interval (QTc) on an electrocardiogram (ECG) as a diagnostic method for CAN in subjects with diabetes mellitus. Method: The prevalence of CAN in a sample of 75 persons with both type 1 and type 2 diabetes mellitus was assessed using Eving's approach, which entailed performing five autonomic function tests. The CAN score in each patient was analysed and its link with the QTc interval was examined. Result: 59 percent of people have CAN. In individuals with type 1 diabetes, univariate analysis revealed a strong correlation between CAN and increased age (odds ratio (OR) 17.59), lengthening of QTc (OR 6.52), duration of disease beyond 10 years (OR 2), and peripheral neuropathy (p,0.001). Conclusion: The majority of people with diabetes mellitus have CAN. Three major risk factors are the duration of diabetes, peripheral neuropathy, and senior age. The ECG’s QTc interval has a reasonable level of sensitivity, specificity, and positive predictive value, making it useful for CAN detection.

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