Abstract

Introduction: Peritonitis is a prevalent issue encountered by General surgeons. Significant advancements in the treatment of peritonitis have occurred in recent decades, primarily through the utilisation of antibiotics and surgical interventions. The objectives of the study were to ascertain the antibiotic sensitivity and resistance pattern for routinely utilised antibiotics against the cultured microbes. Material and Methods: This study was conducted using a cross-sectional design. The research was carried out at the Department of General Surgery, Deccan College of Medical Sciences, Hyderabad, Telangana, India. The study was done from October 2022 to September 2023. This study utilised a sample of 40 persons as subjects. Result: A common complication of perforation of the hollow viscus is secondary peritonitis. Because patients sometimes do not arrive at the hospital until much later, the fatality rate is significant. The age groups of 31–40 years old and 20–30 years old accounted for the bulk of the perforation cases in our study. The average age at which symptoms first appear is 35.26 years. Based on our findings, the second half of the duodenum accounts for 52% of perforations, whereas the stomach accounts for 42%. Among the organisms developed, Klebsiella accounted for 46% of the cases, E. coli for 34%, and just 2% displayed a combination of the two. Our study focused on analysing the sensitivity patterns of organisms that were cultivated. Ceftriaxone, ciprofloxacin, and amikacin were the most commonly found organisms that demonstrated sensitivity. Conclusion: The study found that the most common site of perforation is the duodenum, followed by the stomach. Peptic ulcer illness was the most common cause. The most common bacteria responsible for secondary peritonitis in these patients were Klebsiella and Escherichia coli, with mixed, proteus, and pseudomonas infections occurring very rarely. Cephalosporins, quinolones, and macrolides were the most effective antibiotics against Klebsiella and Escherichia coli, in that order of sensitivity.

Description