Abstract

An investigational short course of antibiotics (two doses of Inj. Cefotaxime 1g IV) was compared to the conventional long course antibiotic for the prevention of postoperative infectious complications in patients undergoing elective caesarean sections at a government tertiary care hospital. To Determine which treatment most successfully stops infectious morbidity, like high body temperature, abnormal vaginal discharge, wound induration, wound discharge, and wound gaping. Methods: A prospective interventional study was undertaken by the Obstetrics and Gynaecology Department at Guntur Medical College in Guntur, Andhra Pradesh, India, from February 2022 to January 2023. For this study, 400 participants were randomly assigned to one of two groups. Two hundred individuals make up each group. Participants were chosen based on whether or not they met the inclusion/exclusion criteria. Result: Two groups of 200 patients each participated in the trial. 162 (81%) of the 200 participants were multi-para, while 38 (19%) were primi-para. 30 (15%) of the first group's 200 patients were primi, 9 (4.5%) were multi gravida, and 161 (80.5%) were multiparas who had previously had LSCS but chose to have another one. Its P value is 0.6. Thirty-six women experienced wound induration, 15 (7.4%) in Group 1 and 21 (10.6%) in Group 2. p=0.09 indicated no statistical significance. Serous wound leakage occurred in 12 (6%) group 1 patients and 15 (7.5%) group 2 patients. 41 (10.25%) of 400 patients had pus discharge, 22 (11%) from Group 1 and 19 (9.5%) from Group 2. Both groups' p values are insignificant. Conclusion: This study found that short-term antibiotics are as effective as long-term ones. Both groups had similar febrile morbidity, wound induration, serous and purulent wound discharge, wound gaping, and abnormal vaginal discharge. Lower-strength antibiotics are increasingly relevant due to antibiotic resistance. The short regimen is cheaper than the extended one since it uses less antibiotics. The short-course antibiotic is safe, effective, convenient, and manpower-saving. Thus, preventing irregular drug administration and replacing the three days of intravenous antibiotics followed by oral antibiotics used in tertiary government centres.

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