Abstract

Introduction: Hospital-acquired infections and community-acquired infections are both linked to Staphylococcus aureus. It has been discovered that staphylococcal isolates from tertiary care hospitals are resistant to widely used antimicrobial drugs. Hospital patient morbidity and death rates have been linked to methicillin-resistant S. aureus (MRSA) with intrinsically established antibiotic resistance. The purpose of this research was to determine the pattern of antibiotic sensitivity of staphylococcal isolates, with a focus on methicillin-resistant S. aureus. Methods: All S. aureus isolates were included in the research after clinical specimens obtained by Kathmandu Medical College-Teaching Hospital between July 2009 and July 2010 were analyzed. The isolations were identified using conventional laboratory techniques.All staphylococcal strains' antibiotic susceptibility patterns were established using the modified Kirby Bauer antibiotic sensitivity technique. Out of 111 isolates of S. aureus, 29 (or 26.12%) were found to be MRSA. For MRSA, the rate of multidrug resistance was 75.86%, while for MSSA, it was 6.09%. Every staphylococcal isolate tested negative for penicillin. All strains, meanwhile, responded well to vancomycin. Conclusions: The Kathmandu Valley's tertiary care hospital has a high frequency of MRSA, according to this research. To lower the frequency of MRSA in hospitals and stop it from spreading to the community, regular surveillance of hospital-associated infections and trend monitoring of antibiotic sensitivity are required. The current research unequivocally demonstrates that the first line of therapy for MRSA infection is still vancomycin. The use of vancomycin should be restricted to situations when it is obviously necessary in order to retain its usefulness.

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