Abstract

C-reactive protein (CRP) is an acute-phase protein that manifests in the blood within 6–10 hours in severe states of COVID-19 hyper inflammatory response, which results in a pathological dysfunction of innate host defense mechanisms. One of the biomarkers of inflammation in bacterial or viral infection is the iron storage form known as ferritin. In this retrospective study, our goal was to assess the diagnostic efficacy of CRP, ferritin, LDH, and D-dimer in identifying COVID-19 positive cases in India. Methods: This research was carried out retrospectively at the Malla Reddy Institute of Medical Sciences in Hyderabad, India. A tertiary care teaching institution's electronic medical records from July 2020 and May 2021 were examined for the test results for CRP, LDH, ferritin, and D dimer in 172 patients overall. Results: The results in ROC show that when all these parameters are combined, the area under the curve (AUC) of LDH and D-dimer is 0.62, that of LDH and C-reactive protein is 0.68, that of LDH and Ferritin is 0.96, and that of LDH, FERRITIN, D-DIMER, and C-reactive protein is 0.99. Before moving on to a final RT-PCR diagnosis, the severity of COVID-19 can be evaluated using a combination of common laboratory biomarkers (CRP, LDH, ferritin, and D- dimer) with a recognized sensitivity and specificity. Conclusion: Prior to moving forward with a formal diagnosis by RT-PCR, a combination of common laboratory biomarkers (CRP, LDH, ferritin, and D-dimer) can be used to predict the diagnosis of COVID-19 with a recognized sensitivity and specificity.

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